Setting description

Taxel therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 2 333 0 0
TP53- & AR- 4 337 3 1
TP53+ 0 294 0 0
DRD+ 0 128 0 0
TEfus+ 0 250 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.004 0.666 0.000 0.000
TP53- & AR- 0.008 0.674 0.006 0.002
TP53+ 0.000 0.588 0.000 0.000
DRD+ 0.000 0.256 0.000 0.000
TEfus+ 0.000 0.500 0.000 0.000
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 103 0 81 60
TP53- & AR- 400 0 415 392
TP53+ 217 0 208 235
DRD+ 126 0 187 192
TEfus+ 206 0 222 206
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.206 0 0.162 0.120
TP53- & AR- 0.800 0 0.830 0.784
TP53+ 0.434 0 0.416 0.470
DRD+ 0.252 0 0.374 0.384
TEfus+ 0.412 0 0.444 0.412
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 13 10 18 26
TP53+ 21 43 22 20
DRD+ 0 0 0 0
TEfus+ 0 0 0 3
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.026 0.020 0.036 0.052
TP53+ 0.042 0.086 0.044 0.040
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.006


Errors & power

The overall error was 0.338.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.012             0.324             0.006             0.002 

The overall power was 0.666.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.666             0.000             0.000 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 2 333 0 0
futility 0 103 0 81 60
max_n 0 0 0 0 0
n 425 (347, 469) 156 (87, 240) 127 (39, 247) 170 (103, 254) 164 (99, 245)
n_unique 395 (328, 436) 144 (80, 223) 118 (36, 235) 156 (97, 239) 152 (92, 230)
time_trial 36 (36, 36) 36 (25, 36) 23 (6, 36) 36 (31, 36) 36 (35, 36)
time_stop NA (NA, NA) 26 (6, 35) 14 (6, 29) 29 (20, 36) 29 (22, 35)
post_p NA (NA, NA) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0.01)
rate 0.075 (0.069, 0.081) 0.113 (0.102, 0.131) 0.036 (0.031, 0.042) 0.113 (0.102, 0.126) 0.113 (0.102, 0.127)
TP53- & AR- graduation 0 4 337 3 1
futility 0 400 0 415 392
max_n 0 13 10 18 26
n 168 (102, 203) 41 (26, 126) 30 (12, 105) 47 (26, 126) 49 (26, 132)
n_unique 158 (94, 190) 38 (25, 118) 28 (12, 100) 43 (24, 119) 46 (24, 125)
time_trial 36 (36, 36) 20 (9, 36) 18 (10, 36) 22 (13, 36) 23 (14, 36)
time_stop NA (NA, NA) 17 (8, 30) 12 (9, 25) 20 (13, 31) 20 (13, 31)
post_p NA (NA, NA) 0.02 (0, 0.12) 1 (0.95, 1) 0.02 (0, 0.12) 0.01 (0, 0.13)
rate 0.075 (0.066, 0.085) 0.114 (0.098, 0.144) 0.036 (0.027, 0.047) 0.115 (0.098, 0.146) 0.115 (0.097, 0.148)
TP53+ graduation 0 0 294 0 0
futility 0 217 0 208 235
max_n 0 21 43 22 20
n 198 (169, 220) 74 (29, 130) 52 (21, 150) 81 (36, 140) 75 (37, 134)
n_unique 184 (157, 206) 68 (27, 122) 48 (19, 140) 75 (34, 131) 70 (34, 126)
time_trial 36 (36, 36) 36 (16, 36) 28 (10, 36) 36 (19, 36) 36 (18, 36)
time_stop NA (NA, NA) 24 (13, 34) 16 (9, 30) 24 (13, 35) 24 (15, 33)
post_p NA (NA, NA) 0.01 (0, 0.09) 1 (0.99, 1) 0.01 (0, 0.08) 0.01 (0, 0.1)
rate 0.075 (0.067, 0.084) 0.115 (0.097, 0.145) 0.036 (0.029, 0.044) 0.114 (0.097, 0.137) 0.113 (0.097, 0.138)
DRD+ graduation 0 0 128 0 0
futility 0 126 0 187 192
max_n 0 0 0 0 0
n 109 (89, 126) 48 (23, 75) 25 (4, 55) 55 (33, 80) 55 (33, 83)
n_unique 101 (82, 117) 44 (22, 69) 23 (3, 52) 51 (30, 76) 51 (32, 78)
time_trial 36 (36, 36) 36 (26, 36) 36 (21, 36) 36 (20, 36) 36 (19, 36)
time_stop NA (NA, NA) 29 (21, 34) 24 (16, 33) 26 (15, 34) 25 (15, 33)
post_p NA (NA, NA) 0.03 (0, 0.24) 1 (0.8, 1) 0.02 (0, 0.19) 0.02 (0, 0.18)
rate 0.075 (0.063, 0.089) 0.113 (0.095, 0.152) 0.036 (0.022, 0.056) 0.115 (0.095, 0.137) 0.115 (0.096, 0.142)
TEfus+ graduation 0 0 250 0 0
futility 0 206 0 222 206
max_n 0 0 0 0 3
n 151 (127, 173) 59 (28, 97) 39 (16, 95) 64 (33, 104) 65 (34, 101)
n_unique 140 (118, 160) 55 (26, 90) 37 (15, 88) 59 (31, 97) 60 (31, 94)
time_trial 36 (36, 36) 36 (20, 36) 36 (12, 36) 36 (19, 36) 36 (21, 36)
time_stop NA (NA, NA) 25 (17, 35) 18 (10, 30) 26 (16, 35) 26 (17, 34)
post_p NA (NA, NA) 0.01 (0, 0.13) 1 (0.98, 1) 0.01 (0, 0.12) 0.01 (0, 0.12)
rate 0.075 (0.065, 0.086) 0.116 (0.096, 0.149) 0.036 (0.027, 0.046) 0.115 (0.097, 0.139) 0.113 (0.097, 0.14)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 421 472 420 396
futility 0 0 0 0 0
max_n 0 13 9 18 26
n 109 (67, 135) 24 (15, 81) 21 (8, 74) 26 (10, 85) 25 (10, 83)
n_unique 103 (62, 127) 23 (14, 77) 20 (7, 71) 24 (9, 81) 23 (9, 80)
post_p NA (NA, NA) 0.05 (0, 0.26) 1 (0.88, 1) 0.08 (0.01, 0.28) 0.07 (0, 0.33)
rate 0.075 (0.064, 0.088) 0.115 (0.094, 0.158) 0.036 (0.025, 0.051) 0.114 (0.093, 0.16) 0.115 (0.091, 0.169)
—+ graduation 0 435 481 440 416
futility 0 0 0 0 0
max_n 0 12 9 17 26
n 18 (10, 26) 6 (3, 18) 4 (2, 11) 6 (2, 16) 6 (2, 16)
n_unique 16 (9, 25) 6 (2, 16) 4 (1, 11) 5 (2, 15) 5 (2, 15)
post_p NA (NA, NA) 0.3 (0.1, 0.57) 0.83 (0.5, 0.98) 0.3 (0.11, 0.55) 0.3 (0.1, 0.58)
rate 0.075 (0.049, 0.114) 0.124 (0.076, 0.242) 0.038 (0.014, 0.081) 0.127 (0.079, 0.32) 0.127 (0.075, 0.321)
–+- graduation 0 233 423 210 235
futility 0 0 0 0 0
max_n 0 21 40 22 20
n 69 (54, 82) 17 (8, 54) 19 (5, 61) 20 (6, 58) 17 (6, 54)
n_unique 65 (51, 79) 16 (7, 52) 18 (5, 57) 18 (6, 55) 16 (5, 51)
post_p NA (NA, NA) 0.11 (0.02, 0.36) 0.99 (0.78, 1) 0.13 (0.02, 0.37) 0.14 (0.02, 0.41)
rate 0.076 (0.062, 0.092) 0.119 (0.089, 0.188) 0.037 (0.025, 0.056) 0.118 (0.089, 0.192) 0.116 (0.091, 0.202)
–++ graduation 0 307 450 299 309
futility 0 0 0 0 0
max_n 0 20 38 20 21
n 45 (33, 55) 11 (5, 32) 13 (6, 37) 14 (4, 37) 12 (4, 35)
n_unique 42 (31, 52) 10 (4, 31) 12 (5, 35) 13 (4, 35) 11 (4, 33)
post_p NA (NA, NA) 0.16 (0.04, 0.44) 0.97 (0.74, 1) 0.17 (0.04, 0.43) 0.18 (0.05, 0.45)
rate 0.075 (0.056, 0.094) 0.122 (0.087, 0.227) 0.038 (0.023, 0.056) 0.12 (0.086, 0.218) 0.118 (0.082, 0.238)
-+– graduation 0 429 478 434 415
futility 0 0 0 0 0
max_n 0 13 9 17 26
n 18 (10, 27) 5 (0, 16) 3 (0, 10) 7 (4, 18) 7 (3, 20)
n_unique 17 (9, 25) 4 (0, 15) 2 (0, 9) 7 (3, 17) 7 (3, 19)
post_p NA (NA, NA) 0.3 (0.11, 0.53) 0.8 (0.49, 0.97) 0.26 (0.09, 0.55) 0.26 (0.1, 0.57)
rate 0.075 (0.049, 0.114) 0.129 (0.079, 0.356) 0.038 (0.006, 0.091) 0.123 (0.079, 0.239) 0.123 (0.079, 0.238)
-+-+ graduation 0 442 486 451 429
futility 0 0 0 0 0
max_n 0 12 9 16 26
n 18 (10, 26) 5 (1, 16) 2 (0, 9) 7 (3, 19) 7 (3, 19)
n_unique 16 (9, 25) 4 (1, 15) 2 (0, 9) 6 (3, 18) 7 (3, 17)
post_p NA (NA, NA) 0.32 (0.12, 0.57) 0.78 (0.47, 0.96) 0.28 (0.1, 0.56) 0.27 (0.1, 0.54)
rate 0.076 (0.051, 0.109) 0.134 (0.076, 0.375) 0.039 (0, 0.108) 0.126 (0.081, 0.242) 0.127 (0.079, 0.259)
-++- graduation 0 262 434 267 287
futility 0 0 0 0 0
max_n 0 19 39 22 20
n 12 (7, 17) 5 (1, 12) 2 (0, 8) 6 (2, 12) 5 (2, 12)
n_unique 11 (6, 16) 5 (1, 11) 2 (0, 8) 5 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.35 (0.15, 0.65) 0.74 (0.47, 0.93) 0.37 (0.15, 0.63) 0.33 (0.15, 0.63)
rate 0.075 (0.045, 0.12) 0.131 (0.069, 0.391) 0.041 (0.008, 0.104) 0.12 (0.068, 0.298) 0.129 (0.071, 0.385)
-+++ graduation 0 327 457 330 338
futility 0 0 0 0 0
max_n 0 18 37 20 21
n 12 (7, 17) 5 (1, 12) 2 (0, 7) 6 (2, 12) 6 (2, 12)
n_unique 11 (7, 16) 4 (1, 11) 2 (0, 7) 5 (2, 11) 5 (2, 12)
post_p NA (NA, NA) 0.36 (0.15, 0.65) 0.75 (0.44, 0.94) 0.34 (0.15, 0.63) 0.33 (0.15, 0.59)
rate 0.076 (0.047, 0.132) 0.13 (0.07, 0.353) 0.036 (0, 0.117) 0.122 (0.071, 0.288) 0.125 (0.072, 0.294)
+— graduation 0 105 333 81 60
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 21 (15, 27) 7 (3, 16) 10 (3, 23) 7 (3, 17) 7 (3, 16)
n_unique 19 (13, 26) 6 (3, 15) 9 (3, 22) 7 (3, 16) 6 (3, 15)
post_p NA (NA, NA) 0.26 (0.11, 0.53) 0.92 (0.61, 0.99) 0.29 (0.11, 0.56) 0.28 (0.11, 0.54)
rate 0.076 (0.052, 0.107) 0.126 (0.081, 0.263) 0.037 (0.018, 0.07) 0.12 (0.078, 0.249) 0.124 (0.075, 0.267)
+–+ graduation 0 230 403 224 207
futility 0 0 0 0 0
max_n 0 0 0 0 3
n 17 (11, 23) 6 (2, 14) 6 (2, 16) 6 (2, 15) 6 (2, 15)
n_unique 16 (10, 22) 5 (2, 14) 5 (2, 16) 5 (2, 14) 5 (2, 14)
post_p NA (NA, NA) 0.29 (0.14, 0.56) 0.86 (0.53, 0.98) 0.31 (0.13, 0.57) 0.31 (0.13, 0.6)
rate 0.075 (0.051, 0.115) 0.127 (0.073, 0.293) 0.037 (0.016, 0.075) 0.13 (0.072, 0.303) 0.126 (0.074, 0.337)
+-+- graduation 0 233 423 210 235
futility 0 0 0 0 0
max_n 0 21 40 22 20
n 17 (11, 22) 6 (2, 14) 5 (2, 14) 7 (2, 15) 6 (2, 14)
n_unique 16 (10, 21) 5 (2, 13) 5 (1, 13) 6 (2, 14) 5 (2, 14)
post_p NA (NA, NA) 0.32 (0.13, 0.58) 0.85 (0.54, 0.98) 0.29 (0.11, 0.59) 0.31 (0.13, 0.61)
rate 0.076 (0.051, 0.116) 0.129 (0.071, 0.285) 0.038 (0.015, 0.08) 0.126 (0.073, 0.311) 0.125 (0.069, 0.298)
+-++ graduation 0 307 450 299 309
futility 0 0 0 0 0
max_n 0 20 38 20 21
n 17 (11, 23) 6 (2, 14) 4 (2, 13) 6 (2, 15) 6 (2, 15)
n_unique 15 (10, 22) 5 (2, 14) 4 (1, 12) 6 (2, 14) 6 (2, 14)
post_p NA (NA, NA) 0.3 (0.12, 0.59) 0.84 (0.52, 0.98) 0.31 (0.13, 0.57) 0.3 (0.14, 0.61)
rate 0.076 (0.05, 0.109) 0.129 (0.074, 0.336) 0.035 (0.014, 0.085) 0.125 (0.078, 0.299) 0.125 (0.074, 0.301)
++– graduation 0 166 372 189 195
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (7, 16) 5 (2, 11) 3 (0, 10) 6 (2, 11) 5 (2, 12)
n_unique 11 (6, 15) 5 (2, 10) 3 (0, 10) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.35 (0.18, 0.63) 0.76 (0.48, 0.95) 0.32 (0.14, 0.63) 0.32 (0.15, 0.62)
rate 0.077 (0.04, 0.126) 0.123 (0.069, 0.28) 0.04 (0.011, 0.092) 0.128 (0.069, 0.291) 0.129 (0.071, 0.308)
++-+ graduation 0 271 429 283 279
futility 0 0 0 0 0
max_n 0 0 0 0 3
n 12 (7, 17) 5 (1, 11) 2 (0, 9) 5 (2, 11) 5 (2, 12)
n_unique 11 (7, 16) 5 (1, 11) 2 (0, 8) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.36 (0.17, 0.64) 0.77 (0.47, 0.94) 0.34 (0.15, 0.63) 0.34 (0.15, 0.66)
rate 0.079 (0.045, 0.13) 0.129 (0.068, 0.368) 0.036 (0, 0.106) 0.127 (0.07, 0.318) 0.125 (0.067, 0.267)
+++- graduation 0 262 434 267 287
futility 0 0 0 0 0
max_n 0 19 39 22 20
n 12 (7, 17) 5 (1, 12) 2 (0, 9) 5 (2, 12) 5 (2, 11)
n_unique 11 (7, 17) 4 (1, 11) 2 (0, 8) 5 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.35 (0.17, 0.64) 0.76 (0.45, 0.96) 0.34 (0.15, 0.59) 0.32 (0.15, 0.63)
rate 0.074 (0.044, 0.121) 0.125 (0.07, 0.358) 0.035 (0.001, 0.119) 0.125 (0.073, 0.302) 0.125 (0.072, 0.285)
++++ graduation 0 327 457 330 338
futility 0 0 0 0 0
max_n 0 18 37 20 21
n 12 (8, 17) 5 (1, 12) 2 (0, 8) 5 (2, 12) 5 (2, 12)
n_unique 11 (7, 16) 4 (1, 11) 2 (0, 7) 5 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.35 (0.16, 0.64) 0.76 (0.46, 0.94) 0.34 (0.14, 0.64) 0.34 (0.16, 0.62)
rate 0.077 (0.047, 0.126) 0.134 (0.074, 0.398) 0.036 (0, 0.107) 0.124 (0.071, 0.324) 0.13 (0.075, 0.326)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 2 333
time_stop 4 (4, 5) 14 (6, 29)
n_trt 32 (30, 34) 86 (34, 205)
n_control 51 (45, 57) 142 (58, 338)
post_p 0.87 (0.86, 0.89) 1 (0.95, 1)
order 1 (1, 1) 2 (1, 4)
TP53- & AR- count 4 337 3 1
time_stop 8 (7, 11) 12 (9, 25) 12 (11, 13) 11 (11, 11)
n_trt 28 (25, 33) 32 (26, 85) 31 (27, 37) 35 (35, 35)
n_control 32 (28, 39) 53 (35, 119) 53 (52, 61) 39 (39, 39)
post_p 0.88 (0.85, 0.9) 0.98 (0.9, 1) 0.9 (0.89, 0.95) 0.91 (0.91, 0.91)
order 1 (1, 1.7) 1 (1, 3) 1 (1, 1.8) 2 (2, 2)
TP53+ count 294
time_stop 16 (9, 30)
n_trt 51 (29, 124)
n_control 73 (39, 160)
post_p 1 (0.97, 1)
order 2 (1, 4)
DRD+ count 128
time_stop 24 (16, 33)
n_trt 30 (25, 50)
n_control 66 (41, 103)
post_p 1 (0.96, 1)
order 3 (2, 5)
TEfus+ count 250
time_stop 18 (10, 30)
n_trt 39 (26, 77)
n_control 69 (33, 126)
post_p 1 (0.96, 1)
order 3 (1, 5)
Futility:
signature var Hormone_therapies Carboplatin Niraparib
all count 103 81 60
time_stop 26 (8, 35) 29 (20, 36) 29 (22, 35)
n_trt 101 (47, 175) 124 (78, 229) 114 (83, 173)
n_control 301 (81, 420) 329 (207, 413) 334 (229, 408)
post_p 0 (0, 0.02) 0 (0, 0) 0 (0, 0)
order 5 (1, 9) 6 (4, 9) 6 (3.9, 10.1)
TP53- & AR- count 400 415 392
time_stop 17 (8, 30) 20 (13, 31) 20 (13, 31)
n_trt 37 (26, 94) 41 (26, 101) 40 (25, 91)
n_control 76 (32, 157) 94 (55, 158) 97 (56, 157)
post_p 0.07 (0, 0.23) 0.06 (0, 0.21) 0.06 (0.01, 0.19)
order 2 (1, 6) 3 (1, 6) 3 (1, 6)
TP53+ count 217 208 235
time_stop 24 (13, 34) 24 (13, 35) 24 (15, 33)
n_trt 50 (27, 100) 57 (28, 115) 53 (30, 93)
n_control 119 (57, 184) 126 (63, 187) 125 (66, 178)
post_p 0.01 (0, 0.09) 0.01 (0, 0.07) 0.01 (0, 0.08)
order 4 (1, 8) 4 (1, 8) 4 (1, 7)
DRD+ count 126 187 192
time_stop 29 (21, 34) 26 (15, 34) 25 (15, 33)
n_trt 39 (26, 64) 42 (28, 67) 42 (29, 59)
n_control 83 (56, 112) 74 (42, 108) 72 (36, 104)
post_p 0.02 (0, 0.09) 0.02 (0, 0.08) 0.02 (0, 0.09)
order 6 (3, 9) 5 (2, 9) 4 (2, 8)
TEfus+ count 206 222 206
time_stop 25 (17, 35) 26 (16, 35) 26 (17, 34)
n_trt 46 (27, 82) 50 (28, 90) 48 (30, 80)
n_control 101 (59, 150) 105 (57, 149) 103 (62, 144)
post_p 0.01 (0, 0.07) 0.01 (0, 0.06) 0.01 (0, 0.08)
order 5 (2, 9) 5 (2, 9) 5 (2, 9)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5)
n 14 (13, 15) 4 (3, 4) 7 (7, 7) 2 (2, 3) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (0, 2) 2 (1, 3) 1 (1, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.61 (0.58, 0.64) 0.56 (0.55, 0.56) 0.54 (0.52, 0.56) 0.56 (0.55, 0.57) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) 0.59 (0.53, 0.66) 0.51 (0.5, 0.51) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.077 (0.073, 0.081) 0 (0, 0) 0.04 (0.008, 0.073) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.219 (0.219, 0.219) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 333 333 333 333 333 333 333 333 333 333 333 333 333 333 333 333
time 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29) 14 (6, 29)
n 18 (6, 47) 4 (1, 8) 13 (4, 42) 11 (5, 24) 2 (0, 6) 2 (0, 7) 1 (0, 6) 2 (0, 5) 7 (3, 17) 5 (2, 12) 4 (2, 11) 4 (1, 10) 2 (0, 7) 1 (0, 6) 1 (0, 7) 1 (0, 5)
post_p 0.92 (0.58, 1) 0.62 (0.52, 0.9) 0.84 (0.56, 1) 0.77 (0.55, 0.99) 0.62 (0.52, 0.89) 0.61 (0.52, 0.88) 0.61 (0.52, 0.83) 0.6 (0.52, 0.83) 0.64 (0.52, 0.97) 0.61 (0.52, 0.89) 0.6 (0.52, 0.91) 0.62 (0.52, 0.9) 0.61 (0.51, 0.87) 0.6 (0.52, 0.86) 0.61 (0.52, 0.88) 0.61 (0.51, 0.84)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.033 (0, 0.059) 0.021 (0, 0.071) 0.032 (0, 0.061) 0.033 (0, 0.059) 0.014 (0, 0.075) 0 (0, 0.078) 0 (0, 0.066) 0 (0, 0.073) 0.028 (0, 0.072) 0.028 (0, 0.077) 0.029 (0, 0.077) 0.024 (0, 0.074) 0.013 (0, 0.084) 0 (0, 0.076) 0 (0, 0.064) 0 (0, 0.074)
TP53- & AR- Hormone_therapies count 4 4 4 4
time 8 (7, 11) 8 (7, 11) 8 (7, 11) 8 (7, 11)
n 22 (20, 29) 3 (3, 4) 1 (0, 1) 0 (0, 2)
post_p 0.77 (0.72, 0.91) 0.58 (0.53, 0.61) 0.58 (0.57, 0.59) 0.55 (0.54, 0.56)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.059 (0.04, 0.075) 0 (0, 0.092) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 337 337 337 337
time 12 (9, 25) 12 (9, 25) 12 (9, 25) 12 (9, 25)
n 23 (16, 65) 4 (2, 12) 3 (1, 9) 3 (1, 9)
post_p 0.92 (0.77, 1) 0.65 (0.52, 0.87) 0.6 (0.52, 0.86) 0.61 (0.52, 0.84)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.034 (0.013, 0.056) 0.031 (0, 0.073) 0 (0, 0.079) 0 (0, 0.084)
Carboplatin count 3 3 3 3
time 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13)
n 19 (15, 25) 3 (2, 5) 5 (4, 6) 3 (3, 5)
post_p 0.85 (0.75, 0.89) 0.57 (0.54, 0.7) 0.63 (0.59, 0.75) 0.66 (0.62, 0.69)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.055 (0.023, 0.061) 0 (0, 0) 0.038 (0.008, 0.053) 0.064 (0.048, 0.092)
Niraparib count 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 16 (16, 16) 1 (1, 1) 13 (13, 13) 5 (5, 5)
post_p 0.73 (0.73, 0.73) 0.59 (0.59, 0.59) 0.72 (0.72, 0.72) 0.58 (0.58, 0.58)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.069 (0.069, 0.069) 0 (0, 0) 0.085 (0.085, 0.085) 0.049 (0.049, 0.049)
TP53+ Taxel_therapies count 294 294 294 294 294 294 294 294
time 16 (9, 30) 16 (9, 30) 16 (9, 30) 16 (9, 30) 16 (9, 30) 16 (9, 30) 16 (9, 30) 16 (9, 30)
n 19 (8, 47) 14 (7, 30) 2 (0, 7) 2 (0, 6) 5 (2, 12) 5 (2, 12) 2 (0, 7) 2 (0, 7)
post_p 0.93 (0.72, 1) 0.86 (0.72, 0.99) 0.61 (0.52, 0.85) 0.63 (0.52, 0.86) 0.71 (0.53, 0.92) 0.67 (0.52, 0.92) 0.65 (0.52, 0.88) 0.64 (0.52, 0.85)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.034 (0.01, 0.053) 0.033 (0.014, 0.058) 0 (0, 0.079) 0 (0, 0.079) 0.031 (0, 0.075) 0.03 (0, 0.069) 0 (0, 0.069) 0 (0, 0.072)
DRD+ count 128 128 128 128 128 128 128 128
time 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33)
n 4 (1, 12) 4 (1, 11) 3 (0, 8) 3 (1, 7) 4 (2, 9) 4 (1, 9) 4 (0, 9) 3 (0, 8)
post_p 0.76 (0.54, 0.95) 0.74 (0.55, 0.94) 0.69 (0.54, 0.9) 0.68 (0.54, 0.88) 0.71 (0.52, 0.9) 0.7 (0.53, 0.92) 0.74 (0.55, 0.92) 0.73 (0.53, 0.92)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.032 (0, 0.086) 0.032 (0, 0.08) 0.031 (0, 0.08) 0.03 (0, 0.085) 0.031 (0, 0.086) 0.03 (0, 0.077) 0.027 (0, 0.065) 0.03 (0, 0.093)
TEfus+ count 250 250 250 250 250 250 250 250
time 18 (10, 30) 18 (10, 30) 18 (10, 30) 18 (10, 30) 18 (10, 30) 18 (10, 30) 18 (10, 30) 18 (10, 30)
n 4 (2, 10) 14 (8, 27) 3 (1, 8) 2 (0, 5) 5 (3, 13) 5 (2, 10) 2 (0, 6) 2 (0, 5)
post_p 0.71 (0.54, 0.91) 0.87 (0.71, 0.99) 0.67 (0.52, 0.9) 0.63 (0.53, 0.83) 0.72 (0.52, 0.92) 0.7 (0.53, 0.9) 0.62 (0.52, 0.86) 0.62 (0.52, 0.82)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.031 (0, 0.074) 0.034 (0.015, 0.056) 0.021 (0, 0.081) 0 (0, 0.074) 0.033 (0, 0.071) 0.031 (0, 0.067) 0 (0, 0.078) 0 (0, 0.085)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 103 103 103 103 103 103 103 103 103 103 103 103 103 103 103 103
time 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35) 26 (8, 35)
n 22 (13, 59) 5 (2, 11) 12 (6, 37) 6 (3, 17) 4 (0, 11) 4 (0, 10) 3 (0, 8) 3 (0, 7) 4 (1, 12) 4 (1, 8) 4 (1, 9) 3 (1, 9) 3 (0, 8) 3 (0, 9) 2 (0, 8) 3 (0, 6)
post_p 0.12 (0.01, 0.42) 0.3 (0.12, 0.46) 0.17 (0.04, 0.41) 0.22 (0.07, 0.44) 0.36 (0.13, 0.48) 0.33 (0.18, 0.45) 0.34 (0.21, 0.46) 0.35 (0.16, 0.46) 0.28 (0.14, 0.44) 0.38 (0.18, 0.48) 0.33 (0.17, 0.47) 0.34 (0.16, 0.48) 0.36 (0.21, 0.47) 0.34 (0.2, 0.46) 0.36 (0.2, 0.48) 0.34 (0.18, 0.46)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.115 (0.093, 0.157) 0.132 (0.078, 0.283) 0.12 (0.085, 0.223) 0.135 (0.091, 0.296) 0.133 (0.083, 0.298) 0.156 (0.091, 0.471) 0.178 (0.095, 0.629) 0.144 (0.095, 0.461) 0.14 (0.09, 0.329) 0.131 (0.069, 0.295) 0.143 (0.07, 0.409) 0.141 (0.082, 0.449) 0.148 (0.095, 0.428) 0.156 (0.076, 0.562) 0.146 (0.089, 0.566) 0.194 (0.103, 0.532)
Carboplatin count 81 81 81 81 81 81 81 81 81 81 81 81 81 81 81 81
time 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36) 29 (20, 36)
n 21 (9, 57) 4 (2, 12) 14 (6, 52) 8 (3, 28) 7 (3, 12) 6 (3, 13) 4 (2, 9) 4 (1, 11) 5 (2, 12) 5 (2, 12) 4 (1, 10) 5 (2, 13) 4 (2, 8) 5 (2, 9) 4 (2, 10) 4 (1, 8)
post_p 0.12 (0.01, 0.36) 0.32 (0.1, 0.47) 0.17 (0.04, 0.44) 0.22 (0.04, 0.43) 0.28 (0.1, 0.46) 0.29 (0.11, 0.45) 0.34 (0.17, 0.45) 0.33 (0.15, 0.45) 0.31 (0.14, 0.45) 0.32 (0.18, 0.47) 0.32 (0.15, 0.45) 0.35 (0.14, 0.45) 0.31 (0.2, 0.44) 0.36 (0.21, 0.48) 0.36 (0.15, 0.48) 0.34 (0.15, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.114 (0.084, 0.158) 0.14 (0.087, 0.329) 0.119 (0.09, 0.189) 0.134 (0.09, 0.251) 0.131 (0.084, 0.27) 0.133 (0.088, 0.31) 0.135 (0.094, 0.44) 0.15 (0.091, 0.459) 0.137 (0.092, 0.303) 0.121 (0.08, 0.265) 0.17 (0.093, 0.909) 0.126 (0.083, 0.324) 0.154 (0.087, 0.297) 0.134 (0.077, 0.462) 0.127 (0.081, 0.274) 0.144 (0.097, 0.328)
Niraparib count 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60 60
time 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35)
n 18 (9, 49) 5 (2, 12) 12 (6, 36) 8 (3, 25) 6 (4, 14) 6 (3, 11) 4 (1, 7) 4 (2, 8) 5 (2, 9) 4 (1, 9) 4 (2, 8) 5 (1, 9) 4 (2, 8) 4 (2, 7) 4 (2, 9) 4 (1, 7)
post_p 0.09 (0.01, 0.36) 0.31 (0.12, 0.45) 0.18 (0.05, 0.39) 0.24 (0.09, 0.41) 0.26 (0.11, 0.42) 0.28 (0.11, 0.42) 0.32 (0.14, 0.44) 0.34 (0.17, 0.47) 0.33 (0.17, 0.47) 0.32 (0.18, 0.45) 0.32 (0.17, 0.47) 0.35 (0.19, 0.46) 0.32 (0.17, 0.45) 0.35 (0.18, 0.47) 0.35 (0.2, 0.48) 0.37 (0.17, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.122 (0.092, 0.198) 0.137 (0.096, 0.314) 0.118 (0.091, 0.213) 0.122 (0.088, 0.249) 0.135 (0.094, 0.218) 0.143 (0.096, 0.313) 0.166 (0.08, 0.44) 0.134 (0.08, 0.262) 0.123 (0.088, 0.325) 0.176 (0.089, 0.596) 0.148 (0.077, 0.314) 0.13 (0.082, 0.258) 0.161 (0.1, 0.352) 0.149 (0.081, 0.342) 0.12 (0.08, 0.241) 0.153 (0.102, 0.404)
TP53- & AR- Hormone_therapies count 400 400 400 400
time 17 (8, 30) 17 (8, 30) 17 (8, 30) 17 (8, 30)
n 23 (15, 59) 6 (3, 14) 4 (0, 14) 4 (1, 13)
post_p 0.17 (0.02, 0.41) 0.37 (0.18, 0.48) 0.41 (0.19, 0.48) 0.41 (0.2, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.115 (0.088, 0.155) 0.123 (0.076, 0.258) 0.138 (0.081, 0.447) 0.145 (0.087, 0.407)
Carboplatin count 415 415 415 415
time 20 (13, 31) 20 (13, 31) 20 (13, 31) 20 (13, 31)
n 22 (9, 65) 5 (2, 13) 7 (3, 14) 6 (3, 15)
post_p 0.22 (0.03, 0.45) 0.38 (0.17, 0.48) 0.36 (0.15, 0.47) 0.35 (0.15, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.112 (0.084, 0.172) 0.139 (0.084, 0.373) 0.123 (0.081, 0.256) 0.13 (0.079, 0.256)
Niraparib count 392 392 392 392
time 20 (13, 31) 20 (13, 31) 20 (13, 31) 20 (13, 31)
n 21 (10, 57) 5 (2, 12) 7 (3, 15) 6 (3, 15)
post_p 0.2 (0.04, 0.44) 0.39 (0.16, 0.49) 0.36 (0.16, 0.48) 0.36 (0.15, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.113 (0.085, 0.176) 0.133 (0.084, 0.371) 0.126 (0.081, 0.242) 0.129 (0.083, 0.28)
TP53+ Hormone_therapies count 217 217 217 217 217 217 217 217
time 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34)
n 14 (8, 40) 8 (4, 22) 3 (1, 8) 3 (1, 8) 4 (2, 11) 5 (2, 11) 3 (1, 9) 3 (1, 8)
post_p 0.16 (0.05, 0.41) 0.24 (0.06, 0.45) 0.38 (0.22, 0.48) 0.37 (0.19, 0.48) 0.37 (0.17, 0.48) 0.35 (0.17, 0.48) 0.4 (0.2, 0.48) 0.38 (0.22, 0.48)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.12 (0.086, 0.188) 0.125 (0.084, 0.249) 0.15 (0.085, 0.476) 0.15 (0.084, 0.479) 0.135 (0.073, 0.335) 0.132 (0.081, 0.424) 0.138 (0.077, 0.426) 0.148 (0.085, 0.483)
Carboplatin count 208 208 208 208 208 208 208 208
time 24 (13, 35) 24 (13, 35) 24 (13, 35) 24 (13, 35) 24 (13, 35) 24 (13, 35) 24 (13, 35) 24 (13, 35)
n 13 (6, 46) 9 (3, 29) 4 (2, 9) 4 (1, 10) 4 (1, 10) 5 (2, 12) 4 (2, 10) 4 (1, 9)
post_p 0.21 (0.05, 0.45) 0.24 (0.07, 0.46) 0.37 (0.2, 0.47) 0.36 (0.18, 0.48) 0.34 (0.14, 0.48) 0.36 (0.15, 0.47) 0.36 (0.18, 0.48) 0.39 (0.19, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.118 (0.086, 0.203) 0.125 (0.086, 0.25) 0.135 (0.086, 0.33) 0.136 (0.083, 0.4) 0.15 (0.086, 0.378) 0.138 (0.081, 0.396) 0.136 (0.079, 0.425) 0.137 (0.085, 0.334)
Niraparib count 235 235 235 235 235 235 235 235
time 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33)
n 13 (5, 35) 8 (4, 26) 4 (1, 9) 4 (2, 9) 4 (1, 10) 4 (2, 11) 4 (2, 9) 4 (2, 8)
post_p 0.21 (0.04, 0.44) 0.26 (0.08, 0.46) 0.35 (0.17, 0.47) 0.37 (0.18, 0.48) 0.37 (0.2, 0.48) 0.35 (0.17, 0.47) 0.37 (0.18, 0.48) 0.37 (0.19, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.118 (0.085, 0.245) 0.124 (0.089, 0.237) 0.154 (0.084, 0.46) 0.135 (0.08, 0.351) 0.136 (0.081, 0.364) 0.141 (0.089, 0.361) 0.136 (0.081, 0.319) 0.147 (0.083, 0.43)
DRD+ Hormone_therapies count 126 126 126 126 126 126 126 126
time 29 (21, 34) 29 (21, 34) 29 (21, 34) 29 (21, 34) 29 (21, 34) 29 (21, 34) 29 (21, 34) 29 (21, 34)
n 5 (1, 14) 5 (1, 14) 4 (1, 10) 4 (1, 10) 4 (2, 9) 4 (1, 10) 4 (1, 9) 3 (1, 8)
post_p 0.36 (0.16, 0.47) 0.32 (0.14, 0.47) 0.38 (0.21, 0.48) 0.36 (0.18, 0.48) 0.37 (0.2, 0.48) 0.35 (0.19, 0.47) 0.36 (0.19, 0.48) 0.35 (0.17, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.082, 0.298) 0.144 (0.087, 0.379) 0.135 (0.082, 0.522) 0.141 (0.09, 0.397) 0.134 (0.084, 0.281) 0.152 (0.084, 0.457) 0.139 (0.087, 0.364) 0.15 (0.088, 0.562)
Carboplatin count 187 187 187 187 187 187 187 187
time 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34)
n 7 (3, 14) 7 (3, 14) 4 (2, 10) 4 (1, 10) 4 (2, 8) 4 (2, 9) 4 (1, 9) 4 (2, 9)
post_p 0.33 (0.11, 0.48) 0.33 (0.12, 0.48) 0.37 (0.18, 0.48) 0.36 (0.2, 0.47) 0.35 (0.2, 0.47) 0.36 (0.19, 0.48) 0.38 (0.15, 0.48) 0.36 (0.15, 0.48)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.128 (0.087, 0.245) 0.127 (0.084, 0.257) 0.125 (0.079, 0.327) 0.141 (0.084, 0.417) 0.136 (0.078, 0.333) 0.145 (0.076, 0.365) 0.135 (0.081, 0.464) 0.143 (0.088, 0.38)
Niraparib count 192 192 192 192 192 192 192 192
time 25 (15, 33) 25 (15, 33) 25 (15, 33) 25 (15, 33) 25 (15, 33) 25 (15, 33) 25 (15, 33) 25 (15, 33)
n 7 (3, 14) 6 (3, 14) 4 (1, 9) 4 (2, 8) 4 (2, 8) 4 (2, 9) 4 (2, 9) 4 (2, 8)
post_p 0.32 (0.13, 0.46) 0.32 (0.13, 0.47) 0.37 (0.16, 0.47) 0.37 (0.2, 0.47) 0.37 (0.2, 0.48) 0.38 (0.17, 0.48) 0.38 (0.2, 0.48) 0.37 (0.19, 0.47)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.137 (0.089, 0.267) 0.131 (0.094, 0.262) 0.147 (0.083, 0.435) 0.135 (0.082, 0.376) 0.142 (0.075, 0.342) 0.145 (0.083, 0.356) 0.14 (0.078, 0.327) 0.145 (0.087, 0.395)
TEfus+ Hormone_therapies count 206 206 206 206 206 206 206 206
time 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35) 25 (17, 35)
n 6 (3, 16) 9 (5, 25) 4 (1, 12) 4 (1, 9) 5 (2, 11) 5 (2, 11) 4 (1, 10) 3 (1, 9)
post_p 0.3 (0.13, 0.46) 0.23 (0.08, 0.45) 0.35 (0.17, 0.47) 0.37 (0.18, 0.47) 0.34 (0.16, 0.48) 0.35 (0.16, 0.46) 0.4 (0.21, 0.48) 0.35 (0.2, 0.47)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.081, 0.265) 0.127 (0.083, 0.248) 0.15 (0.091, 0.381) 0.145 (0.078, 0.466) 0.126 (0.079, 0.295) 0.135 (0.084, 0.336) 0.145 (0.084, 0.458) 0.158 (0.094, 0.458)
Carboplatin count 222 222 222 222 222 222 222 222
time 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35)
n 5 (2, 13) 10 (3, 29) 6 (3, 14) 4 (2, 10) 5 (2, 11) 5 (2, 12) 5 (2, 9) 4 (2, 10)
post_p 0.34 (0.14, 0.46) 0.25 (0.06, 0.47) 0.31 (0.14, 0.46) 0.38 (0.19, 0.47) 0.37 (0.16, 0.48) 0.35 (0.15, 0.48) 0.37 (0.23, 0.48) 0.38 (0.18, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.139 (0.089, 0.326) 0.128 (0.085, 0.227) 0.129 (0.082, 0.265) 0.141 (0.079, 0.373) 0.146 (0.081, 0.384) 0.135 (0.08, 0.373) 0.134 (0.079, 0.399) 0.142 (0.085, 0.331)
Niraparib count 206 206 206 206 206 206 206 206
time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
n 5 (2, 12) 9 (3, 28) 6 (3, 14) 4 (2, 8) 4 (1, 10) 4 (2, 11) 4 (2, 9) 4 (1, 9)
post_p 0.34 (0.13, 0.48) 0.27 (0.09, 0.46) 0.31 (0.12, 0.48) 0.36 (0.17, 0.48) 0.36 (0.17, 0.47) 0.35 (0.15, 0.47) 0.37 (0.18, 0.48) 0.38 (0.19, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.139 (0.088, 0.33) 0.122 (0.081, 0.278) 0.131 (0.079, 0.3) 0.142 (0.079, 0.32) 0.149 (0.086, 0.405) 0.137 (0.084, 0.355) 0.141 (0.083, 0.318) 0.144 (0.087, 0.398)